Have you read Sklansky's Theory of Poker? It's an old but good book. He talks about how the idea of poker is to get people to make mistakes, which he defines as getting them to play their hand differently from how they would play it if they could see your cards. In this case, even though you're a favorite, 22 would call if it could see your hand (unless your bet was HUGE) because of the pot odds he is getting. So if you knew he had 22, you'd prefer to make him fold, even though you're a slight favorite. That's because when he folds, you increase your equity in the current pot from 60% to 100%, and that's worth more than putting a bit more money into the pot as a 60% favorite.

Pot odds are a function of the size of the bet relative to the size of the pot. You want your opponent to call when he does not have the correct pot odds to call, and to fold when he does have the correct pot odds to call.

Importantly, even if you can't make your opponent fold, you'd still rather him call from behind but getting the correct odds than give him a free card. This is why it's correct to, for instance, shove in the last of your money with top pair even if you know your opponent has a flush draw and there isn't enough money behind to charge him an incorrect price to draw.